Research relating to Revayo Prime’s ingredients.
This page summarises selected peer-reviewed studies involving specific collagen peptide ingredients and separates ingredient research from claims about Revayo Prime. Study populations, designs, doses and limitations vary. References are linked to PubMed below.
Collagen is a structural protein found throughout the body. This page reviews selected studies on hydrolysed collagen peptide ingredients and the authorised vitamin C claim. It does not claim that Revayo Prime was used in those studies.
Hydrolysed collagen peptides are collagen proteins broken into smaller peptide chains. The selected papers below investigated specific ingredients, populations and endpoints; they should be interpreted study by study.
The selected trials used daily doses from 5g to 15g and ran for 12 to 24 weeks. Their methods and endpoints differed, so dose comparisons alone do not establish that products or outcomes are equivalent.
The following two randomised, placebo-controlled studies investigated activity-related joint-comfort measures in their stated populations. They did not test Revayo Prime as a finished product.
Study 1
Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides
A 12-week randomised, double-blind, placebo-controlled trial conducted at the University of Freiburg with 139 athletic subjects experiencing functional knee discomfort. Participants ingested 5g of specific bioactive collagen peptides (FORTIGEL®) or a placebo daily. The trial reported a statistically significant improvement in activity-related pain intensity in the collagen group compared with placebo, confirmed independently by both participant self-assessment and physician assessment.
Study 2
24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain
A 24-week randomised, double-blind, placebo-controlled trial conducted at Penn State University with 147 college-level athletes (72 male, 75 female) with activity-related joint discomfort and no diagnosed joint disease. Participants ingested 10g of collagen hydrolysate or placebo daily. Six parameters - including joint pain at rest, joint pain when walking, joint pain when standing, and joint pain when carrying objects - showed statistically significant improvement in the collagen group versus placebo over the 24-week study period.
These trials tested specified collagen peptide ingredients under controlled conditions. Neither trial tested Revayo Prime as a finished product, and differences in population, intervention, dose, duration and endpoints limit extrapolation.
The following study examined a defined athlete population with chronic ankle instability. It should be read as a report of that study, not as advice for managing an injury.
Study 3
Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability
A 6-month randomised, double-blind, placebo-controlled trial with 50 male and female athletes diagnosed with chronic ankle instability following previous ankle sprains. Participants ingested 5g of specific collagen peptides or placebo daily. Subjective perceived ankle stability - measured by two validated tools (CAIT and FAAM-G) - improved statistically significantly in the collagen group versus placebo. A 3-month follow-up period reported a statistically significant decline in the number of ankle joint re-injuries in the collagen group.
The authors reported outcomes in their specified study population. The findings should not be extrapolated to other joints, injury prevention or Revayo Prime.
Collagen is an incomplete protein and is not a substitute for whey or another complete protein source. The following study investigated measured body-composition and muscle-proteome outcomes alongside a resistance-training programme.
Study 4
Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men
A 12-week randomised, double-blind, placebo-controlled trial with 25 recreationally active men undertaking a structured hypertrophy resistance training programme. Participants ingested 15g of specific collagen peptides or placebo within 60 minutes after each training session. Vastus lateralis muscle biopsies were taken before and after the intervention. The collagen group showed statistically significant increases in fat-free mass compared with placebo, alongside upregulation of muscle proteome markers including myotilin - a Z-disk protein associated with myofibril remodelling following exercise.
This was a small study with a specified intervention and population. It did not test Revayo Prime, and its findings should not be treated as a promised training or body-composition outcome.
Hydrolysis breaks collagen into smaller peptides. Human studies have detected certain food-derived collagen peptides in blood after ingestion; detection does not by itself establish a health outcome.
Study 5 identified food-derived collagen peptide fragments, including proline-hydroxyproline, in human blood after gelatin hydrolysate ingestion.[5] Mechanistic research has separately investigated peptide interactions with cells and tissues; mechanistic observations do not demonstrate a clinical benefit from Revayo Prime.
Hydrolysed collagen differs from complete dietary proteins in its amino-acid and peptide profile. The cited evidence should not be interpreted as proving superior absorption or a guaranteed clinical effect.
The selected studies used daily collagen-peptide quantities within a 5g to 15g range and study durations of 12 to 24 weeks. Comparing dose alone does not establish equivalence between ingredients, finished products or outcomes.
Revayo Prime provides 14.77g of FORTIGEL® hydrolysed bovine collagen peptides per 15g serving. This quantity describes the formula; it does not mean the finished product was tested in the cited trials.
The Vitamin C connection
Vitamin C has an authorised health claim relating to normal collagen formation. Revayo uses this permitted statement below rather than extending it to treatment, pain, injury or recovery claims.
Vitamin C contributes to normal collagen formation for the normal function of cartilage, bones, skin, blood vessels, gums and teeth. This is the relevant authorised health statement used for Revayo Prime.
Revayo Prime provides 189.9mg vitamin C per 15g serving. The authorised statement applies to vitamin C; it is not a claim that Revayo Prime prevents, treats or cures a condition.
Revayo Prime is formulated with FORTIGEL®, a named hydrolysed bovine collagen peptide ingredient produced by GELITA AG. Selected publications involving specific collagen peptide ingredients are cited on this page.
Study 1 used FORTIGEL® at 5g daily in its stated study population. Revayo Prime provides 14.77g FORTIGEL® collagen peptides per serving, but a higher quantity does not establish greater efficacy or make the finished Revayo product equivalent to the study intervention.
FORTIGEL® is a branded hydrolysed collagen peptide ingredient with a defined manufacturing specification. Ingredient identity and quantity do not establish that the finished Revayo product will reproduce the outcome of any individual trial.
FORTIGEL® is a registered trademark of GELITA AG.
- Revayo Prime is not a painkiller. It should not be used for immediate or acute pain relief.
- Revayo Prime does not treat or reverse arthritis or any other diagnosed disease.
- Collagen is not a substitute for complete protein. It is lower in essential amino acids than whey, casein and other complete protein sources.
- No individual outcome is promised. Study findings depend on the population, intervention, comparator, duration and endpoints used.
- Persistent or worsening symptoms warrant assessment by a qualified healthcare professional, not a supplement.
Taken together, these papers show what researchers have investigated; they do not establish guaranteed or universal benefits and they did not test Revayo Prime as a finished product. Each finding should be interpreted alongside the study population, ingredient, dose, duration, endpoints and limitations. For Revayo Prime, the permitted health statement is the vitamin C claim above.
- Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Applied Physiology, Nutrition, and Metabolism. 2017;42(6):588–595. PubMed: 28177710
- Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, Deitch JR, Sherbondy PS, Albert A. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion. 2008;24(5):1485–1496. PubMed: 18416885
- Dressler P, Gehring D, Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability. Journal of Sports Science and Medicine. 2018;17(2):298–304. PubMed: 29769831
- Oertzen-Hagemann V, Kirmse M, Eggers B, Pfeiffer K, Marcus K, de Marées M, Platen P. Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men. Nutrients. 2019;11(5):1072. PubMed: 31086001
- Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, Higashi A, Kido Y, Nakabo Y, Ohtsuki K. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. Journal of Agricultural and Food Chemistry. 2005;53(16):6531–6536. PubMed: 16076145